Paracompletion Question 5 - CAT 2025

Question

Sentence: In each of the affected males, the genetic defect was located to the X chromosome in the region of p11-12.

Paragraph: The first suggested evidence of a human genetic mutation associated with aggressive behaviour came from a study in 1993. __(1)__ . Genetic and metabolic studies were conducted on a large Dutch family in which several of the males has a syndrome of borderline mental retardation and abnormal behaviour. __(2)__ . The undesirable behaviour included impulsive aggression, arson and exhibitionism. __(3)__ . A point mutation was identified in the eighth exon of the monoamine oxidase A (MAOA) structural gene which changes glutamine to a termination codon. __(4)__.

  • A. Option 3
  • B. Option 4
  • C. Option 2
  • D. Option 1

Step-by-Step Explanation

The sentence fits best in blank (3) because the paragraph first introduces the study, then talks about the Dutch family and the unusual behaviour found in the affected males. After mentioning behaviours such as aggression, arson, and exhibitionism, it makes sense to explain where the genetic problem was found — on the X chromosome in the p11-12 region. The paragraph can then move on to the more specific finding about the point mutation in the MAOA gene.

The other positions don’t fit as well. Blank (1) is too early because the study and the family have not been properly introduced yet. Blank (2) would interrupt the explanation of the family and the studies carried out on them. Blank (4) comes after the paragraph has already given the detailed mutation finding, so mentioning the chromosome location there would feel out of order.

Therefore, Blank (3) is the correct answer.

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